FivePrime’s strategy is to discover the next generation of commercially important protein therapeutics by screening the complete set of human extracellular proteins (secreted proteins and the extracellular domains of receptors) in medically relevant cell-based and in vivo screens. FivePrime’s unique and integrated technologies make this achievable at commercially attractive costs and in accelerated timeframes: 

FivePrime Protein Library : FivePrime has built the world’s largest collections of full-length human cDNAs and has used this collection to create a comprehensive library of secreted proteins, extracellular domains of receptors, and peptide hormones. This collection includes all of the proteins that form the basis of marketed blockbuster protein drugs as well as thousands of additional proteins. 

Cell Based Discovery Platform : FivePrime’s cell-based discovery platform combines a high throughput protein production system with medically relevant cell-based assays to enable the rapid evaluation of potential protein candidates on a variety of cell types. These assays typically use freshly isolated primary cells and complex assay designs and readouts to best mimic disease physiology. 

Rapid In Vivo Protein Production System (RIPPS^SM) : FivePrime’s proprietary in vivo screening system enables the rapid and cost effective evaluation of protein therapeutic candidates in mouse models of human disease.

Receptor-Ligand Matching : FivePrime’s receptor-ligand matching technologies provide crucial knowledge about the fundamental biology and potential side effects of newly discovered therapeutic receptors or ligands and helps guide the design of the best drug candidates. 

Protein Therapeutic Development Technologies : FivePrime’s state of the art technologies include tools for protein purification, protein engineering, optimization of mammalian cell lines for large scale protein manufacturing, and formulation development to enhance drug efficacy and minimize side effects.

• Comprehensive and systematic approach

• Complete high quality library of all human extracellular proteins

• Technologies  applied at industrial scale across therapeutic areas

• Medically-relevant assays self validating—also identifies hits that are known drugs 

• Accelerates the discovery and development process